রবিবার, ১০ মার্চ, ২০১৩

We're live at Elon Musk's SXSW keynote

We're live at Elon Musk's SXSW keynote

Electric cars and commercial space flight -- what more could a person want? The Tesla / SpaceX founder is bringing all of that to his keynote on this, this second day of South By Southwest Interactive. The exec has never been on to mince words, so this ought to be an interesting one. Join us after the break, won't you?

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Source: http://www.engadget.com/2013/03/09/were-live-at-elon-musks-sxsw-keynote/

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শুক্রবার, ৮ মার্চ, ২০১৩

Path 3 Now Does Messaging

Path, the social networking app that does a little bit of everything, has added some new features in its latest update. Path 3.0 now does private messaging (one-to-one or group), has something called 'Stickers' which are like Emojis on steroids and is opening up a new shop for you to buy stuff from. Basically, more of a little of everything. More »


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/6R3u6r3jInQ/path-3-now-does-messaging

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Chavez body to be put on permanent display

A large image of Venezuela's late President Hugo Chavez is on display where mourners line up to view his body lying in state at the military academy in Caracas, Thursday, March 7, 2013. While Venezuela remains deeply divided over the country's future, the multitudes weeping and crossing themselves as they reached the president's coffin early Thursday were united in grief and admiration for a man many considered a father figure. (AP Photo/Ariana Cubillos)

A large image of Venezuela's late President Hugo Chavez is on display where mourners line up to view his body lying in state at the military academy in Caracas, Thursday, March 7, 2013. While Venezuela remains deeply divided over the country's future, the multitudes weeping and crossing themselves as they reached the president's coffin early Thursday were united in grief and admiration for a man many considered a father figure. (AP Photo/Ariana Cubillos)

Venezuela's Vice President Nicolas Maduro speaks to the crowd at the military academy where the body of Venezuela's late President Hugo Chavez is lying in state in Caracas, Venezuela, Thursday, March 7, 2013. Maduro, Venezuela's acting president, said Chavez's remains will be put on permanent display at the Museum of the Revolution, close to the presidential palace where Chavez ruled for 14 years. A state funeral for Chavez attended by some 33 heads of government is scheduled to begin Friday morning. (AP Photo/Rodrigo Abd)

In this photo provided by Miraflores Presidential Press Office, mourners pay their respects as they file past the glass-topped casket containing the remains of Venezuela's late President Hugo Chavez lying in state at the military academy in Caracas, Thursday, March 7, 2013. Chavez died of a massive heart attack Tuuesday after great suffering and inaudibly mouthed his desire to live, the head of Venezuela's presidential guard said late Wednesday. (AP Photo/Miraflores Presidential Press Office)

Mourners walk over a barrier outside the military academy where Venezuela's late President Hugo Chavez's body lies in state at the military academy in Caracas, Venezuela, Thursday, March 7, 2013. While Venezuela remains deeply divided over the country's future, the multitudes who reached the president's coffin early Thursday were united in grief and admiration for a man many considered a father figure. (AP Photo/Ariana Cubillos)

A woman cries as she waits to see the body of Venezuela's late President Hugo Chavez at the military academy where his body is lying in state in Caracas, Venezuela, Thursday, March 7, 2013. While Venezuela remains deeply divided over the country's future, the multitudes who reached the president's coffin were united in grief and admiration for a man many considered a father figure. (AP Photo/Ariana Cubillos)

(AP) ? Hugo Chavez's body will be preserved and forever displayed inside a glass tomb at a military museum not far from the presidential palace from which he ruled for 14 years, his successor announced Thursday in a Caribbean version of the treatment given Communist revolutionary leaders such as Lenin, Mao and Ho Chi Minh.

Vice President Nicolas Maduro, Venezuela's acting head of state, said Chavez would first lie in state for "at least" seven more days before the museum becomes his permanent home. It was not clear when exactly he would be moved from the military academy where his body has been since Wednesday.

Later Thursday, the National Assembly speaker announced that Maduro would be sworn in Friday night as acting president following a state funeral and would call elections within 30 days. That enables him, as the designated governing party candidate, to run for president as Chavez desired. Legal scholars say that under the constitution, the legislature's speaker should instead be sworn in and organize the vote.

More than 30 heads of government, including Cuban President Raul Castro and Iranian leader Mahmoud Ahmadinejad are to attend the funeral. U.S. Rep. Gregory Meeks, a New York Democrat, and former Rep. William Delahunt, a Democrat from Massachusetts, will represent the United States, which Chavez often portrayed as a great global evil even as he sent the country billions of dollars in oil each year.

Maduro said the ceremony would begin at 11 a.m., but did not say where.

"We have decided to prepare the body of our 'Comandante President,' to embalm it so that it remains open for all time for the people. Just like Ho Chi Minh. Just like Lenin. Just like Mao Zedong," Maduro said.

He said the body would be held in a "crystal urn" at the Museum of the Revolution, a mile from Miraflores presidential palace.

The announcement followed two emotional days in which Chavez's supporters compared him to Jesus Christ, and accused his national and international critics of seeking to undermine his "revolution."

A sea of sobbing, heartbroken humanity jammed Venezuela's main military academy Thursday to see Chavez's body, some waiting 10 hours under the twinkling stars and the searing Caribbean sun to file past his coffin.

On Thursday night, Castro, Presidents Jose Mujica of Uruguay and and Dilma Rousseff of Brazil viewed the open casket along with former Brazilian president Inacio Lula da Silva.

But even as his supporters attempted to immortalize the dead president, a country exhausted from round-the-clock mourning began to look toward the future. Some worried openly whether the nation's anointed leaders are up to filling his shoes, and others said they were anxious for news on when elections will be held. The constitution mandates they be called within 30 days, but the government has yet to address the matter.

"People are beginning to get back to their lives. One must keep working," said 40-year-old Caracas resident Laura Guerra, a Chavez supporter who said she was not yet sold on Maduro. "I don't think he will be the same. I don't think he has the same strength that the 'comandante' had."

At the military academy, Chavez lay in a glass-covered coffin wearing the olive-green military uniform and red beret of his paratrooper days and looking gaunt and pale, his lips pressed together. In a nod to the insecurity that plagues this country, mourners had to submit to a pat down, pass through a metal detector and remove the batteries from their mobile phones before they entered.

As they reached the coffin, many placed a hand on their heart or stiffly saluted. Some held up children so they could see Chavez's face.

"I waited 10 hours to see him, but I am very happy, proud to have seen my comandante," said 46-year-old Yudeth Hurtado, sobbing. "He is planted in our heart."

Government leaders had been largely incommunicado Wednesday as they marched in a seven-hour procession that brought Chavez's body from a military hospital to the academy. They finally emerged before the cameras Thursday but offered no answers.

Asked when an election would be held, Foreign Minister Elias Jaua said only that the constitution would be followed.

Jaua also struck the defiant, us-against-the-world tone that the government has projected, which some critics fear could incite passions in a country that remains on edge.

"They couldn't defeat him electorally, they couldn't assassinate him, they couldn't beat him militarily," Jaua declared. "Chavez died as president ... Chavez died the leader of his people."

Just hours before the 58-year-old president's death on Tuesday, Maduro expelled two U.S. diplomats and lashed out at opponents at home and abroad. He implied that the cancer that ultimately killed Chavez was somehow injected into him by his enemies, a charge echoed by Ahmadinejad.

While Maduro is the clear favorite over likely opposition candidate Henrique Capriles, the nation is polarized between Chavez supporters and critics who hold him responsible for soaring inflation, a growing national debt and a jump in violent crime.

Opponents have also questioned the government's allegiance to the rule of law, arguing that Maduro is not entitled to become interim president under the 1999 constitution. They have also criticized the defense minister, Adm. Diego Molero, for pledging support for Maduro's candidacy despite a ban on the military taking political sides.

Ana Teresa Sifontes, a 71-year-old housewife and opposition sympathizer, said Chavez did some good for the nation's poor. But she said he had bungled the economy, exhibiting more interest in regional grandstanding than governing.

She said she hoped his death would bring change.

"Why do we have to pay for Cuba?" she asked, referring to the billions in Venezuelan oil Chavez sent to Havana each year in return for Cuban doctors and other experts. "Why do we need them here?"

Venezuelan officials have yet to say what type of cancer he suffered from, but details were emerging of the former paratrooper's final hours.

The head of Venezuela's presidential guard, Gen. Jose Ornella, told the AP late Wednesday that Chavez died of a massive heart attack after great suffering.

"He couldn't speak but he said it with his lips ... 'I don't want to die. Please don't let me die,' because he loved his country, he sacrificed himself for his country," said Ornella, who said he was with the socialist president at the moment of his death Tuesday.

In Washington, State Department Spokeswoman Victoria Nuland said the U.S. hoped the upcoming vote would be held on a level playing field, and lamented the expulsion of the American officials.

"We are obviously disappointed by these false accusations levied against our embassy officials," Nuland said. "This is part of a tired playbook of alleging foreign interference as a political football in internal Venezuelan politics."

___

Associated Press writers Fabiola Sanchez, Frank Bajak and Christopher Toothaker contributed to this report.

___

Paul Haven on Twitter: www.twitter.com/paulhaven

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2013-03-07-Venezuela-Chavez/id-3676c360ca8b4e65afc98c1c613182f9

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Folate and vitamin B12 reduce disabling schizophrenia symptoms in some patients

Mar. 6, 2013 ? Adding the dietary supplements folate and vitamin B12 to treatment with antipsychotic medication improved a core symptom component of schizophrenia in a study of more than 100 patients. The study focused on negative symptoms of schizophrenia -- which include apathy, social withdrawal, and a lack of emotional expressiveness. While the level of improvement across all participants was modest, results were more significant in individuals carrying specific variants in genes involved with folate metabolism. The report from a team based at Massachusetts General Hospital (MGH) will appear in the journal JAMA Psychiatry (formerly Archives of General Psychiatry) and has been issued online.

"The symptoms of schizophrenia are complex, and antipsychotic medications provide no relief for some of the most disabling parts of the illness. These include negative symptoms, which can be particularly devastating," says Joshua Roffman, MD, MMSc, of the MGH Department of Psychiatry, corresponding author of the JAMA Psychiatry paper. "Our finding that folate plus vitamin B12 supplementation can improve negative symptoms opens a new potential avenue for treatment of schizophrenia. Because treatment effects differed based on which genetic variants were present in each participant, the results also support a personalized medical approach to treating schizophrenia."

An essential nutrient, folate (or folic acid) is required for the synthesis of DNA and neurotransmitters and plays a role in the control of gene expression. Adequate folate intake during pregnancy can reduce the risk of birth defects -- in particular neural tube defects -- and studies have suggested that folate deficiency during pregnancy significantly increases the risk of schizophrenia among offspring. Earlier research by members of the MGH-based team associated low blood folate levels with more severe negative symptoms among patients with schizophrenia.

The current study was designed specifically to investigate whether supplementation with folate and B12 -- which can magnify the effects of folate -- reduced negative symptoms of schizophrenia. A 2011 pilot study found symptom improvement only among patients carrying a variant in a folate-pathway gene called MTHFR that reduced the gene's activity. To get a clearer picture of folate's effect on negative symptoms, the current study enrolled 140 patients with schizophrenia at community mental health centers in Boston, Rochester, N.Y., and Grand Rapids, Mich.

Participants were all taking antipsychotic medications -- which have been shown to alleviate positive symptoms, such as hallucinations and delusions, but not negative symptoms -- and were randomized to receive daily doses of either folate and vitamin B12 or a placebo for 16 weeks. Every two weeks their medical and psychiatric status was evaluated, using standard symptom assessment tools along with measurements of blood levels of folate and homocysteine, an amino acid that tends to rise when folate levels drop. Nutritional information was compiled to account for differences in dietary intake of the nutrients. Participants' blood samples were analyzed to determine the variants they carried of MTHFR and three other folate-pathway genes previously associated with the severity of negative symptoms of schizophrenia.

Among all 140 participants in the study protocol, those receiving folate and vitamin B12 showed improvement in negative symptoms, but the degree of improvement was not statistically significant compared with the placebo group. But when the analysis accounted for the variants in the genes of interest, intake of the two nutrients did provide significant improvement in negative symptoms, chiefly reflecting the effects of specific variants in MTHFR and in a gene called FOLH1. Variants in the other two genes studied did not appear to have an effect on treatment outcome.

While a low-functioning variant in FOLH1 had been associated with more severe negative symptoms in previous research, in this study it was the high-functioning FOLH1 variant that predicted a better treatment outcome. Measurement of participants' blood folate levels throughout the study provided an explanation for this unexpected finding. Those with the low-functioning FOLH1 variant started the trial with substantially lower folate levels, suggesting a problem with folate absorption. Although supplementation enabled their blood folate levels to eventually catch up with those of participants with the high-functioning variant, it was probably too late to produce symptom improvement during the 16-week trial period.

"For participants who did show a benefit, it took the full 16 weeks of treatment for that benefit to appear," Roffman explains. "While we don't know why this is the case, changes in gene expression -- which take time -- are a likely explanation. Folate plays a critical role in DNA methylation, which regulates gene expression, so it's plausible that its effects on negative symptoms act through gene expression changes. Participants with the low-functioning FOLH1 variant might eventually show a benefit of folate supplementation if treated for a longer period of time, but that needs to be investigated in future studies."

He adds that, while the benefits of supplementation for the overall group were modest, the lack of effective treatment for negative symptoms and the safety of folate and vitamin B12 supplementation support the need for larger-scale trials. In addition, the impact of genotype on this study's results suggests the need to investigate the role of folate pathway variants in conditions such as dementia and cardiovascular disease, in which low folate appears to increase risk but supplementation trials have had inconclusive results.

"We are now conducting a clinical trial of 1-methylfolate, which bypasses some of these folate-pathway enzymes and might have greater efficiency among individuals with low-functioning variants," explains Roffman, an assistant professor of Psychiatry at Harvard Medical School. "Understanding more about the basic neural mechanisms of folate in patients with schizophrenia could help us generate more targeted and effective interventions to reduce and possibly even prevent symptoms."

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The above story is reprinted from materials provided by Massachusetts General Hospital, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Joshua L. Roffman et al. Randomized Multicenter Investigation of Folate Plus Vitamin B12 Supplementation in Schizophrenia. JAMA Psychiatry, 2013 DOI: 10.1001/jamapsychiatry.2013.900

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/UcXTj8lVfH0/130306162237.htm

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PFT: Falcons, 49ers?interested in Revis

Wes WelkerAP

With Patriots receiver Wes Welker planning to test the market, the question becomes the outcome of the looming experiment.

Per a source with knowledge of the situation, the Pats remain the favorite to retain Welker.? That said, one or two teams could intervene.

?It?s close,? the source explained.

As of Saturday, teams officially can begin talking with the agents of free agents.? Unofficially, conversations surely have happened.

Staying in New England presents a stew of conflicting concerns for Welker.? He surely wants to continue playing with quarterback Tom Brady, even if every time the sure-handed Welker fails to catch a poorly-thrown ball the media and fans deem it a ?drop.?

Then there?s the fact that, before tight end Aaron Hernandez sprained an ankle early in the 2012 regular season, Hernandez appeared to be the team?s new slot receiver, with Welker being phased out.? Welker reportedly fears that could happen again.

And the ?take less to win more? vibe undoubtedly has made its way into the negotiations, with Brady?s recent contract becoming the $27 million elephant in the room.? The Pats know how to get business done on their terms, and if Brady was subtly cajoled into taking less how could anyone else complain?

In the end, Welker has to ask himself whether he wants more money or another chance to finish what the team started in 2007, when he was in his first year of the relatively modest long-term deal that expired after the 2011 season.

Of course, chasing the money also could result in playing with a quarterback whose periodic poor throws won?t be blamed on the guy who wasn?t able to make the difficult catch.

Source: http://profootballtalk.nbcsports.com/2013/03/06/falcons-49ers-on-list-of-possible-revis-trade-partners/related/

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Obama signs expanded domestic violence law (cbsnews)

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